I can think of only one. I have no wisdom on how much weight to give it in the decision making process. Here it is:
In a mainline liberal denomination you will be in a perpetual war against unbelievers who deny essential doctrines like the deity of Christ or his resurrection, etc. But by some iron law of human depravity, all the evidence indicates that moving into an orthodox denomination means engaging in a perpetual war over petty disagreements as if the Gospel were at stake and the opposition were unbelievers.